九州大学 大学院 医学研究院

Makihara N, Arimura K, Ago T, Tachibana M, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, Kuroda J, Sugimori H, Kamouchi M, Kitazono T

Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke.

Exp Neurol 264: 127-34

Irie F, Kamouchi M, Hata J, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kitazono T

Sex differences in short-term outcomes after acute ischemic stroke: the Fukuoka Stroke Registry.

Stroke 46(2): 471-6

Fukuda K, Kai H, Kamouchi M, Hata J, Ago T, Nakane H, Imaizumi T, Kitazono T

Day-by-Day Blood Pressure Variability and Functional Outcome After Acute Ischemic Stroke: Fukuoka Stroke Registry.

Stroke 46(7): 1832-9

Kikuchi Y, Iwase M, Fujii H, Ohkuma T, Kaizu S, Ide H, Jodai T, Idewaki Y, Nakamura U, Kitazono T

Association of severe hypoglycemia with depressive symptoms in patients with type 2 diabetes: the Fukuoka Diabetes Registry.

BMJ Open Diabetes Res Care 3(1): e000063

Ohkuma T, Hirakawa Y, Nakamura U, Kiyohara Y, Kitazono T, Ninomiya T

Association between eating rate and obesity: a systematic review and meta-analysis.

Int J Obes (Lond) 39(11): 1589-96

Ohkuma T, Iwase M, Fujii H, Kaizu S, Ide H, Jodai T, Kikuchi Y, Idewaki Y, Hirakawa Y, Nakamura U, Kitazono T

Dose- and time-dependent association of smoking and its cessation with glycemic control and insulin resistance in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry.

PLoS One 10(3): e0122023

Idewaki Y, Iwase M, Fujii H, Ohkuma T, Ide H, Kaizu S, Jodai T, Kikuchi Y, Hirano A, Nakamura U, Kubo M, Kitazono T

Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry.

PLoS One 10(11): e0143288

Tanaka S, Ninomiya T, Masutani K, Nagata M, Tsuchimoto A, Tsuruya K, Kitazono T

Prognostic impact of serum bilirubin level on long-term renal survival in IgA nephropathy.

Clin Exp Nephrol 19(6): 1062-70

Kakizuka S, Takeda T, Komiya Y, Koba A, Uchi H, Yamamoto M, Furue M, Ishii Y, Yamada H

Dioxin-Produced Alteration in the Profiles of Fecal and Urinary Metabolomes: A Change in Bile Acids and Its Relevance to Toxicity.

Biol Pharm Bull 38(10): 1484-95

Mitoma C, Mine Y, Utani A, Imafuku S, Muto M, Akimoto T, Kanekura T, Furue M, Uchi H

Current skin symptoms of Yusho patients exposed to high levels of 2,3,4,7,8-pentachlorinated dibenzofuran and polychlorinated biphenyls in 1968.

Chemosphere 137: 45-51

Matsumoto S, Akahane M, Kanagawa Y, Kajiwara J, Mitoma C, Uchi H, Furue M, Imamura T

Unexpectedly long half-lives of blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) levels in Yusho patients.

Environ Health 14: 76

Mitoma C, Uchi H, Tsukimori K, Yamada H, Akahane M, Imamura T, Utani A, Furue M

Yusho and its latest findings-A review in studies conducted by the Yusho Group.

Environ Int 82: 41-8

Wu Z, Uchi H, Morino-Koga S, Shi W, Furue M

Z-ligustilide ameliorated ultraviolet B-induced oxidative stress and inflammatory cytokine production in human keratinocytes through upregulation of Nrf2/HO-1 and suppression of NF-κB pathway.

Exp Dermatol 24(9): 703-8

Furue M

Foreword. The Twenty-five Reports of the Study on Yusho--PCBs and Dioxin-Related Compounds

Fukuoka Igaku Zasshi 106(5): 83-4

Akahane M, Matsumoto S, Kanagawa Y, Mitoma C, Uchi H, Yoshimura T, Furue M, Imamura T

[Comparison of the prevalence of symptoms and medical histories between Yusho patients and healthy controls.]

Fukuoka Igaku Zasshi 106(5): 85-118

Matsumoto S, Akahane M, Kanagawa Y, Kajiwara J, Tsukimori K, Wake N, Mitoma C, Uchi H, Furue M, Imamura T

[Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients.]

Fukuoka Igaku Zasshi 106(5): 139-43

Kajiwara J, Todaka T, Hirakawa H, Hori T, Hirata T, Iida T, Uchi H, Furue M

[The Distribution of Dioxin Concentrations in the Blood of Yusho Patients.]

Fukuoka Igaku Zasshi 106(5): 149-53

Yasutake D, Kogiso T, Hori T, Miyawaki T, Yamamoto T, Kajiwara J, Hirata T, Uchi H, Furue M

[Blood PCB Concentrations and their Tendencies Examined in Fukuoka 2011-2014 Annual Inspections for Yusho.]

Fukuoka Igaku Zasshi 106(5): 154-9

Miyawaki T, Hirakawa S, Todaka T, Hirakawa H, Hori T, Kajiwara J, Hirata T, Uchi H, Furue M

A Study on Polychlorinated Biphenyls Specifically--Accumulated in Blood of Yusho Patients Collected from Medical Check-Ups in 2012.

Fukuoka Igaku Zasshi 106(5): 160-8

Yamada K, Ishii Y, Takeda T, Kuroki H, Mitoma C, Uchi H, Furue M, Yamada H

[Effect of Cynaropicrin on 2,3,4,7,8-Pentachlorodibenzofuran-induced Wasting Syndrome and Oxidative Stress.]

Fukuoka Igaku Zasshi 106(5): 169-75

Mitoma C, Uchi H, Tsuji G, Koga S, Furue M

[Latest Findings of Yusho and Its Therapeutic Development.]

Fukuoka Igaku Zasshi 106(5): 184-94

Takei K, Mitoma C, Hashimoto-Hachiya A, Uchi H, Takahara M, Tsuji G, Kido- Nakahara M, Nakahara T, Furue M

Antioxidant soybean tar Glyteer rescues T-helper-mediated downregulation of filaggrin expression via aryl hydrocarbon receptor.

J Dermatol 42(2): 171-80

Furue M, Tsuji G, Mitoma C, Nakahara T, Chiba T, Morino-Koga S, Uchi H

Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor.

J Dermatol Sci 80(2): 83-8

Nakahara T, Mitoma C, Hashimoto-Hachiya A, Takahara M, Tsuji G, Uchi H, Yan X, Hachisuka J, Chiba T, Esaki H, Kido-Nakahara M, Furue M

Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes.

J Med Food 18(10): 1143-9

Liu G, Asanoma K, Takao T, Tsukimori K, Uchi H, Furue M, Kato K, Wake N

Aryl hydrocarbon receptor SNP -130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24.

Toxicol Lett 232(2): 384-92

Takei K, Hashimoto-Hachiya A, Takahara M, Tsuji G, Nakahara T, Furue M

Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway.

Toxicol Lett 234(2): 74-80

Tsukuya G, Matsumoto K, Fukuyama S, Crawford B, Nakanishi Y, Ichinose M, Machida K, Samukawa T, Ninomiya T, Kiyohara Y, Inoue H, Hisayama Pulmonary Physiology Study Group

Validation of a COPD screening questionnaire and establishment of diagnostic cut-points in a Japanese general population: the Hisayama study.

Allergol Int 64(1): 49-53

Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y

Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study.

Atherosclerosis 242(1): 199-204

Takeuchi K, Furuta M, Takeshita T, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y

Risk factors for reduced salivary flow rate in a Japanese population: the Hisayama Study.

Biomed Res Int 2015: 381821

Anno K, Shibata M, Ninomiya T, Iwaki R, Kawata H, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M

Paternal and maternal bonding styles in childhood are associated with the prevalence of chronic pain in a general adult population: the Hisayama Study.

BMC Psychiatry 15: 181

Nagai K, Hayashi K, Yasui T, Katanoda K, Iso H, Kiyohara Y, Wakatsuki A, Kubota T, Mizunuma H

Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses' Health Study baseline survey.

BMJ Open 5(3): e006360

Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y

Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study.

Cardiovasc Diabetol 14: 84

Sato S, Arima H, Heeley E, Hirakawa Y, Delcourt C, Lindley RI, Robinson T, Huang Y, Morgenstern L, Stapf C, Wang J, Chalmers J, Anderson CS, INTERACT2 Investigators

Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial.

Cerebrovasc Dis 40(3-4): 114-20

Huxley RR, Hirakawa Y, Hussain MA, Aekplakorn W, Wang X, Peters SA, Mamun A, Woodward M

Age- and Sex-Specific Burden of Cardiovascular Disease Attributable to 5 Major and Modifiable Risk Factors in 10 Asian Countries of the Western Pacific Region.

Circ J 79(8): 1662-74

Kang A, Nigwekar SU, Perkovic V, Kulshrestha S, Zoungas S, Navaneethan SD, Cass A, Gallagher MP, Ninomiya T, Strippoli GF, Jardine MJ

Interventions for lowering plasma homocysteine levels in kidney transplant recipients.

Cochrane Database Syst Rev (5)CD007910

He L, Tuomilehto J, Qiao Q, Söderberg S, Daimon M, Chambers J, Pitkäniemi J; 12ODA study group (Kiyohara Y)

Impact of classical risk factors of type 2 diabetes among Asian Indian, Chinese and Japanese populations.

Diabetes Metab 41(5): 401-9

Okuda N, Miura K, Okayama A, Okamura T, Abbott RD, Nishi N, Fujiyoshi A, Kita Y, Nakamura Y, Miyagawa N, Hayakawa T, Ohkubo T, Kiyohara Y, Ueshima H; NIPPON DATA80 Research Group (Kiyohara Y)

Fruit and vegetable intake and mortality from cardiovascular disease in Japan: a 24-year follow-up of the NIPPON DATA80 Study.

Eur J Clin Nutr 69(4): 482-8

Nagai M, Ohkubo T, Murakami Y, Takashima N, Kadota A, Miyagawa N, Saito Y, Nishi N, Okuda N, Kiyohara Y, Nakagawa H, Nakamura Y, Fujiyoshi A, Abbott RD, Okamura T, Okayama A, Ueshima H, Miura K; NIPPON DATA80/90/2010 Research Group.

Secular trends of the impact of overweight and obesity on hypertension in Japan, 1980–2010.

Hypertens Res 38(11): 798

Satoh M, Ohkubo T, Asayama K, Murakami Y, Sakurai M, Nakagawa H, Iso H, Okayama A, Miura K, Imai Y, Ueshima H, Okamura T; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH–JAPAN) Research Group (Kiyohara Y)

Combined effect of blood pressure and total cholesterol levels on long-term risks of subtypes of cardiovascular death: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan.

Hypertension 65(3): 517-24

Poppe KK, Whalley GA, Doughty RN, Woodward M, Patel A, Chow CK, Hirakawa Y, Chalmers J, Hillis GS, Triggs CM

The development and feasibility of a composite score of echocardiographic indices that may stratify outcome in patients with diabetes mellitus.

Int J Cardiol 182: 244-249

Hisamatsu T, Miura K, Fujiyoshi A, Okamura T, Ohkubo T, Nagasawa SY, Horie M, Okayama A, Ueshima H; NIPPON DATA80 Research Group (Kiyohara Y)

Long-term outcomes associated with prolonged PR interval in the general Japanese population.

Int J Cardiol 184: 291-293

Ohkuma T, Hirakawa Y, Nakamura U, Kiyohara Y, Kitazono T, Ninomiya T

Association between eating rate and obesity: a systematic review and meta-analysis.

Int J Obes (Lond) 39(11): 1589-96

Fujiwara K, Yasuda M, Ninomiya T, Hata J, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T

Insulin resistance is a risk factor for increased intraocular pressure: the Hisayama Study.

Invest Ophthalmol Vis Sci 56(13): 7983-7

Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y

Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study.

J Am Geriatr Soc 63(11): 2332-9

Sugiyama D, Okamura T, Watanabe M, Higashiyama A, Okuda N, Nakamura Y, Hozawa A, Kita Y, Kadota A, Murakami Y, Miyamatsu N, Ohkubo T, Hayakawa T, Miyamoto Y, Miura K, Okayama A, Ueshima H; NIPPON DATA 80/90 Research Group(Kiyohara Y)

Risk of hypercholesterolemia for cardiovascular disease and the population attributable fraction in a 24-year Japanese cohort study.

J Atheroscler Thromb 22(1): 95-107

Kondo H, Ninomiya T, Hata J, Hirakawa Y, Yonemoto K, Arima H, Nagata M, Tsuruya K, Kitazono T, Kiyohara Y

Angiotensin I-converting enzyme gene polymorphism enhances the effect of hypercholesterolemia on the risk of coronary heart disease in a general Japanese population: the Hisayama Study.

J Atheroscler Thromb 22(4): 390-403

Sato S, Heeley E, Arima H, Delcourt C, Hirakawa Y, Pamidimukkala V, Li Z, Tao Q, Xu Y, Hennerici MG, Robinson T, Tzourio C, Lindley RI, Chalmers J, Anderson CS; INTERACT Investigators; Anderson CS, Huang Y, Wang JG, Arima H, Neal B, Peng B, Heeley E, Skulina C, Parsons MW, Kim JS, Tao QL, Li YC, Jiang JD, Tai LW, Zhang LJ, Xu E, Cheng Y, Heritier S, Morgenstern LB, Chalmers J.

Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2.

J Neurol Neurosurg Psychiatry 86(12): 1319-23

Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, Zhao MH, Lv J, Garg AX, Knight J, Rodgers A, Gallagher M, Kotwal S, Cass A, Perkovic V

Worldwide access to treatment for end-stage kidney disease: a systematic review.

Lancet 385(9981): 1975-82

NCD Risk Factor Collaboration (NCD-RisC)(Kiyohara Y, Ninomiya T)

Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331,288 participants.

Lancet Diabetes Endocrinol 3(8): 624-37

Wang AY, Bellomo R, Cass A, Finfer S, Gattas D, Myburgh J, Chadban S, Hirakawa Y, Ninomiya T, Li Q, Lo S, Barzi F, Sukkar L, Jardine M, Gallagher MP, POST-RENAL Study Investigators and the ANZICS Clinical Trials Group

Health-related quality of life in survivors of acute kidney injury: ｔhe prolonged outcomes study of the randomized evaluation of normal versus augmented level replacement therapy study outcomes.

Nephrology (Carlton) 20(7): 492-8

Arima H, Heeley E, Delcourt C, Hirakawa Y, Wang X, Woodward M, Robinson T, Stapf C, Parsons M, Lavados PM, Huang Y, Wang J, Chalmers J, Anderson CS; INTERACT2 Investigators

Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2.

Neurology 84(5): 464-71

Tsuruya K, Fukuma S, Wakita T, Ninomiya T, Nagata M, Yoshida H, Fujimi S, Kiyohara Y, Kitazono T, Uchida K, Shirota T, Akizawa T, Akiba T, Saito A, Fukuhara S

Dietary patterns and clinical outcomes in hemodialysis patients in Japan: a cohort study.

PLoS One 10(1): e0116677

Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.

Psychiatr Genet 25(4): 139-46

Matsumoto K, Seki N, Fukuyama S, Moriwaki A, Kan-O K, Matsunaga Y, Noda N, Yoshida M, Koto H, Takata S, Nakanishi Y, Kiyohara Y, Inoue H; Hisayama Pulmonary Physiology Study Group

Prevalence of asthma with airflow limitation, COPD, and COPD with variable airflow limitation in older subjects in a general Japanese population: the Hisayama Study.

Respir Investig 53(1): 22-29